2. Academic Validation
  3. The scavenging capacity of γ-aminobutyric acid for acrolein and the cytotoxicity of the formed adduct

The scavenging capacity of γ-aminobutyric acid for acrolein and the cytotoxicity of the formed adduct

  • Food Funct. 2020 Sep 23;11(9):7736-7747. doi: 10.1039/c9fo02518a.
Kaiyu Jiang 1,  Zhao Yin 2,  Ping Zhou 1,  Hongyang Guo 1,  Caihuang Huang 1,  Guangwen Zhang 1,  Wenzhong Hu 3,  Shiyi Ou 1,  Juanying Ou 4
Affiliations

Affiliations

  • 1 Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
  • 2 Institute of Chinese Integrative Medicine, Medical College of Jinan University, Guangzhou 510632, China.
  • 3 College of Life Science, Dalian Minzu University, Dalian 116600 Liaoning, China and Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Dalian 116600 Liaoning, China.
  • 4 Institute of Food Safety & Nutrition, Jinan University, Guangzhou 510632, China. [email protected].
PMID: 32793937 DOI: 10.1039/c9fo02518a
Abstract

Acrolein is a notorious aldehyde with hazardous impacts on humans. γ-Aminobutyric acid (GABA) is a functional amino acid present widely in foods. This study aimed at investigating the protective mechanism of GABA against acrolein. In simulated physiological and thermal processing models, GABA effectively scavenged acrolein by adduct formation. The cytotoxicity of the formed adduct was evaluated in human bronchial epithelial cell line HBE and normal colonic epithelial cell line NCM460. It tremendously decreased acrolein toxicity and exerted protective effects by ROS reduction. Apoptotic staining and signaling analysis showed that it also interfered with Apoptosis via extrinsic and intrinsic pathways. Our findings provide the basic knowledge that GABA is an effective acrolein scavenger and it has potential detoxifying capacity for both exogenous and endogenous acrolein sourced cellular damage.

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