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  2. Precise and tunable time-controlled drug release system using layer-by-layer films as erodible coatings

Precise and tunable time-controlled drug release system using layer-by-layer films as erodible coatings

  • Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111244. doi: 10.1016/j.msec.2020.111244.
Jiafeng Tian 1 Rong Xu 1 Haozheng Wang 1 Ying Guan 2 Yongjun Zhang 3
Affiliations

Affiliations

  • 1 Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
  • 2 Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. Electronic address: [email protected].
  • 3 Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China. Electronic address: [email protected].
Abstract

Unlike conventional drug carriers, time-controlled release systems do not release drug immediately, but start to release drug after a predetermined lag time. Coating a drug-loaded core with an erodible barrier is a valid way to defer drug release, however, the complicated erosion behavior of the erodible coatings makes it difficult to predict and tune the lag time. Herein we proposed that dynamic layer-by-layer films, using hydrogen-bonded poly(ethylene glycol)/tannic acid (PEG/TA) film as an example, are ideal erodible coatings, because their erosion mechanism is clear and simple, and they disintegrate at constant rate. As a proof, we demonstrated that the release of bovine serum albumin (BSA) from BMS spheres can be deferred by PEG/TA coating. More importantly, the lag time can be simply tuned by the thickness of the coating. By mixing bimodal mesoporous silica (BMS) spheres coated with different thickness PEG/TA films, multiple pulse release was achieved. Similar release patterns were also successfully achieved in vivo.

Keywords

Dynamic bonds; Hydrogen bonding; Layer-by-layer assembly; Pulsatile drug release system; Time-controlled drug release system.

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