2. Academic Validation
  3. Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells

Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells

  • J Immunol. 2020 Oct 15;205(8):2169-2187. doi: 10.4049/jimmunol.2000253.
Jens Eberlein 1 2,  Bennett Davenport 1 2 3 4 5,  Tom T Nguyen 1 2 3,  Francisco Victorino 1 2 3,  Kevin Jhun 4 5,  Verena van der Heide 4 5,  Maxim Kuleshov 6 7,  Avi Ma'ayan 6 7,  Ross Kedl 2,  Dirk Homann 8 2 3 4 5
Affiliations

Affiliations

  • 1 Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
  • 2 Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
  • 3 Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
  • 4 Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • 5 Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
  • 6 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029; and.
  • 7 Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • 8 Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; [email protected].
PMID: 32948687 DOI: 10.4049/jimmunol.2000253
Abstract

The choreography of complex immune responses, including the priming, differentiation, and modulation of specific effector T cell populations generated in the immediate wake of an acute pathogen challenge, is in part controlled by chemokines, a large family of mostly secreted molecules involved in chemotaxis and Other patho/physiological processes. T cells are both responsive to various chemokine cues and a relevant source for certain chemokines themselves; yet, the actual range, regulation, and role of effector T cell-derived chemokines remains incompletely understood. In this study, using different in vivo mouse models of viral and Bacterial infection as well as protective vaccination, we have defined the entire spectrum of chemokines produced by pathogen-specific CD8+ and CD4+T effector cells and delineated several unique properties pertaining to the temporospatial organization of chemokine expression patterns, synthesis and secretion kinetics, and cooperative regulation. Collectively, our results position the "T cell chemokine response" as a notably prominent, largely invariant, yet distinctive force at the forefront of pathogen-specific effector T cell activities and establish novel practical and conceptual approaches that may serve as a foundation for future investigations into the role of T cell-produced chemokines in infectious and Other Diseases.

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