2. Academic Validation
  3. Potential of surface plasmon resonance biosensors in cancer detection

Potential of surface plasmon resonance biosensors in cancer detection

  • J Pharm Biomed Anal. 2021 Feb 5:194:113802. doi: 10.1016/j.jpba.2020.113802.
Pawel Falkowski 1,  Zenon Lukaszewski 2,  Ewa Gorodkiewicz 3
Affiliations

Affiliations

  • 1 Faculty of Chemistry, Bioanalysis Laboratory, University of Bialystok, Ciolkowskiego 1K, 15-245, Bialystok, Poland.
  • 2 Poznan University of Technology, Faculty of Chemical Technology, Poland.
  • 3 Faculty of Chemistry, Bioanalysis Laboratory, University of Bialystok, Ciolkowskiego 1K, 15-245, Bialystok, Poland. Electronic address: [email protected].
PMID: 33303267 DOI: 10.1016/j.jpba.2020.113802
Abstract

A review is made of 71 papers on surface plasmon resonance biosensors, published between 2005 and 2020, mostly in the last decade. The reviewed papers are divided into two groups, depending on the validation of the developed biosensor. Validated biosensors are briefly characterized, while those that are not validated are listed in a table. Focus is placed on applications of SPR biosensors in testing the effectiveness of Cancer markers and in the discovery of new Cancer markers. Seven new markers are proposed, two of them having high sensitivity and diagnostic selectivity as determined by ROC curves. Papers concerning the determination of micro RNA and large particles such as vesicles, exosomes and Cancer cells are also reviewed.

Keywords

Biosensors; Body fluids; Circulating cancer markers; Liquid biopsy; ROC curves; Surface plasmon resonance; Validation.

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