2. Academic Validation
  3. Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification

Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification

  • Eur J Med Chem. 2021 Jan 15:210:113092. doi: 10.1016/j.ejmech.2020.113092.
Yuxi Fang 1,  Haonan Li 1,  Bao Ji 1,  Keguang Cheng 2,  Bo Wu 3,  Zhanlin Li 1,  Chao Zheng 4,  Huiming Hua 1,  Dahong Li 5
Affiliations

Affiliations

  • 1 Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
  • 2 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, And School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China.
  • 3 Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, MA, 02129, United States.
  • 4 PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, 06520, United States.
  • 5 Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: [email protected].
PMID: 33333398 DOI: 10.1016/j.ejmech.2020.113092
Abstract

Marine natural products are known for their diverse chemical structures and extensive bioactivities. Renieramycins, the member of tetrahydroisoquinoline family of Marine natural products, arouse interests because of their strong antitumor activities and similar structures to the first marine antitumor agent ecteinascidin-743, approved by the European Union. According to the literatures, researches on the pharmacological activities of renieramycins mainly focus on their antitumor activities. In addition, by structural modification, derivatives of renieramycins show stronger antiproliferative activity and less accidental necrosis activity on cells. Nevertheless, the difficulties in extraction and separation hinder their further development. Hence, the synthetic chemistry work of renieramycins plays a key role in their further development. In this review, currently reported researches on the synthetic chemistry, pharmacological activities and structural modification of renieramycins are summarized, which will benefit future drug development and innovation.

Keywords

Alkaloid; Medicinal chemistry; Renieramycins; Synthetic chemistry.

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