2. Academic Validation
  3. Expanding the View of IKK: New Substrates and New Biology

Expanding the View of IKK: New Substrates and New Biology

  • Trends Cell Biol. 2021 Mar;31(3):166-178. doi: 10.1016/j.tcb.2020.12.003.
Ricardo J Antonia 1,  Robert S Hagan 2,  Albert S Baldwin 3
Affiliations

Affiliations

  • 1 Department of Surgery, Division of Surgical Oncology, and The Hellen Diller Comprehensive Cancer Center, The University of California San Francisco, San Francisco, CA, USA.
  • 2 Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • 3 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: [email protected].
PMID: 33422358 DOI: 10.1016/j.tcb.2020.12.003
Abstract

The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation and innate immunity via their control of the transcription factors NF-κB, IRF3, and IRF7. Novel phosphorylated substrates have been attributed to these kinases, a subset of which is not directly related to either inflammation or innate immunity. These findings have greatly expanded the perspectives on the biological activities of these kinases. In this review we highlight some of the novel substrates for this kinase family and discuss the biological implications of these phosphorylation events.

Keywords

IKKα; IKKβ; IKKε; NF-κB; TBK1; phosphorylation.

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