2. Academic Validation
  3. Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma

Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma

  • Aging (Albany NY). 2021 Mar 24;13(7):10312-10325. doi: 10.18632/aging.202793.
Ya Peng 1,  Zhaoyu Zhang 2 3,  Ailing Zhang 1,  Changhong Liu 2,  Yingnan Sun 3,  Zixuan Peng 2,  Yang Liu 2
Affiliations

Affiliations

  • 1 Hunan Provincial People's Hospital and the Affiliated Hunan Normal University, Changsha 410081, Hunan, China.
  • 2 The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410008, Hunan, China.
  • 3 Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha 410013, Hunan, China.
PMID: 33761465 DOI: 10.18632/aging.202793
Abstract

Annexin A4 (ANXA4) is a Ca2+- and phospholipid-binding protein that belongs to the annexin family, which is involved in the development of multiple tumour types via NF-κB signalling. In this study, we verified the high expression and membrane-cytoplasm translocation of ANXA4 in colorectal carcinoma (CRC). Calcium/calmodulin-dependent protein kinase II gamma (CAMK2γ) was found to be important for high ANXA4 expression in CRC, whereas Carbonic Anhydrase (CA1) promoted ANXA4 aggregation in the cell membrane. An increased Ca2+ concentration attenuated the small ubiquitin-like modifier (SUMO) modification of cytoplasmic ANXA4 and ANXA4 stabilization, and relatively high expression of ANXA4 promoted CRC tumorigenesis and epithelial-mesenchymal transition (EMT).

Keywords

SUMO; annexin A4; calcium/calmodulin-dependent protein kinase II gamma; carbonic anhydrase; membrane-cytoplasm translocation.

Figures
Products