2. Academic Validation
  3. Prenylated coumarins from the fruits of Artocarpus heterophyllus with their potential anti-inflammatory and anti-HIV activities

Prenylated coumarins from the fruits of Artocarpus heterophyllus with their potential anti-inflammatory and anti-HIV activities

  • Nat Prod Res. 2022 May;36(10):2526-2533. doi: 10.1080/14786419.2021.1913590.
Lei Tao 1 2,  Ya-Ting Zhuo 2,  Ze-Hua Qiao 3 4 5,  Juan Li 3 4 5,  Hao-Xuan Tang 3 4 5,  Qiao-Mei Yu 3 4 5,  Yun-Yao Liu 2,  Yan-Ping Liu 2 3 4 5
Affiliations

Affiliations

  • 1 Nanjing Institute for Food and Drug Control, Nanjing, P. R. China.
  • 2 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China.
  • 3 Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
  • 4 Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University, Haikou, P. R. China.
  • 5 Key Laboratory of Research and Development of Tropical Fruit and Vegetable of Haikou City, Hainan Normal University, Haikou, P. R. China.
PMID: 33949253 DOI: 10.1080/14786419.2021.1913590
Abstract

A phytochemical investigation on the fruits of Artocarpus heterophyllus led to the isolation and characterisation of a new prenylated coumarin, artoheteronin (1), together with six known analogues (2-7). The chemical structure of 1 was elucidated using extensive spectral methods and the known compounds (2-7) were identified by comparing their spectral data with those reported in the literature. All known compounds (2-7) were isolated from the genus Artocarpus for the first time. The anti-inflammatory and anti-HIV activities of all isolated prenylated Coumarins (1-7) were assessed in vitro. As a result, compounds 1-7 displayed notable inhibitory effects against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with the IC50 values in range of 0.58 ± 0.06 to 6.29 ± 0.12 μM. Meanwhile, compounds 1-7 exhibited notable anti-HIV-1 Reverse Transcriptase (RT) activities possessing EC50 values in the range of 0.18 to 9.12 µM.

Keywords

Carpus heterophyllus; anti-HIV-1 activities; anti-inflammatory activities; artoheteronin; prenylated coumarins.

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