2. Academic Validation
  3. Advancement of chimeric hybrid drugs to cure malaria infection: An overview with special emphasis on endoperoxide pharmacophores

Advancement of chimeric hybrid drugs to cure malaria infection: An overview with special emphasis on endoperoxide pharmacophores

  • Eur J Med Chem. 2021 Jul 5:219:113408. doi: 10.1016/j.ejmech.2021.113408.
Bhawana Sharma 1,  Preeti Singh 1,  Ashawani Kumar Singh 1,  Satish K Awasthi 2
Affiliations

Affiliations

  • 1 Chemical Biology Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India.
  • 2 Chemical Biology Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India. Electronic address: [email protected].
PMID: 33989911 DOI: 10.1016/j.ejmech.2021.113408
Abstract

Emergence and spread of Plasmodium falciparum resistant to artemisinin-based combination therapy has led to a situation of haste in the scientific and pharmaceutical communities. Sincere efforts are redirected towards finding alternative chemotherapeutic agents that are capable of combating multidrug-resistant Parasite strains. Extensive research yielded the concept of "Chimeric Bitherapy (CB)" which involves the linking of two molecules with individual pharmacological activity and exhibit dual mode of action into a single hybrid molecule. Current research in this field seems to endorse hybrid molecules as the next-generation antimalarial drugs and are more effective compared to the multi-component drugs because of the lower occurrence of drug-drug adverse effects. This review is an attempt to congregate complete survey on endoperoxide based hybrid antiplasmodial molecules that will give glimpse on the future directions for successful development and discovery of useful antimalarial hybrid drugs.

Keywords

Antimalarials; Artemisinin combination therapy; Chimeric bitherapy; Endoperoxide; Hybrid drugs.

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