2. Academic Validation
  3. Copper-Catalyzed Three-Component Reactions of α-Ketoaldehyde, 1,3-Dicarbonyl Compound, and Organic Boronic Acid in Water: A Route to 1,4-Diketones

Copper-Catalyzed Three-Component Reactions of α-Ketoaldehyde, 1,3-Dicarbonyl Compound, and Organic Boronic Acid in Water: A Route to 1,4-Diketones

  • J Org Chem. 2021 Jul 16;86(14):9914-9923. doi: 10.1021/acs.joc.1c01100.
Qi Xia 1,  Xiang Li 1,  Xi Fu 1,  Yaxuan Zhou 1,  Yanqing Peng 1,  Jiayi Wang 1,  Gonghua Song 1
Affiliations

Affiliation

  • 1 Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
PMID: 34181415 DOI: 10.1021/acs.joc.1c01100
Abstract

A novel three-component reaction of α-ketoaldehydes, 1,3-dicarbonyl compounds, and organic boronic acids catalyzed by CuO in water has been developed to give a wide range of products containing 1,3/1,4-diketones. The method has some advantages such as the use of readily available starting Materials, wide substrate scopes, excellent yields, gram-scale synthesis, and mild reaction conditions.

Figures
Products