(4-Boc-aminophenyl)boronic acid
Based on 1 Customer Validation
(4-Boc-aminophenyl) boronic acid is an arylboronic acid. As a substrate in H2O, (4-Boc-aminophenyl) boronic acid participates in the CuO-catalyzed three-component reaction with α-ketoaldehydes and 1,3-dicarbonyl compounds to produce 1,4-diketone products.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 380430-49-9
- Formula: C11H16BNO4
- Molecular Weight:237.06
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(4-Boc-aminophenyl) boronic acid (0.75 mmol; 45−210 min) participates in a nanosized CuO-catalyzed three-component reaction with ethyl glyoxylate and acetylacetone in water at 100 °C, affording the corresponding 1,4-diketone product with a yield of 23%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 380430-49-9
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Appearance Solid
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Molecular Weight 237.06
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Formula C11H16BNO4
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Color White to off-white
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SMILES
CC(C)(OC(NC1=CC=C(B(O)O)C=C1)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (421.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.55 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2183 mL | 21.0917 mL | 42.1834 mL | 105.4585 mL |
| 5 mM | 0.8437 mL | 4.2183 mL | 8.4367 mL | 21.0917 mL | |
| 10 mM | 0.4218 mL | 2.1092 mL | 4.2183 mL | 10.5459 mL | |
| 15 mM | 0.2812 mL | 1.4061 mL | 2.8122 mL | 7.0306 mL | |
| 20 mM | 0.2109 mL | 1.0546 mL | 2.1092 mL | 5.2729 mL | |
| 25 mM | 0.1687 mL | 0.8437 mL | 1.6873 mL | 4.2183 mL | |
| 30 mM | 0.1406 mL | 0.7031 mL | 1.4061 mL | 3.5153 mL | |
| 40 mM | 0.1055 mL | 0.5273 mL | 1.0546 mL | 2.6365 mL | |
| 50 mM | 0.0844 mL | 0.4218 mL | 0.8437 mL | 2.1092 mL | |
| 60 mM | 0.0703 mL | 0.3515 mL | 0.7031 mL | 1.7576 mL | |
| 80 mM | 0.0527 mL | 0.2636 mL | 0.5273 mL | 1.3182 mL | |
| 100 mM | 0.0422 mL | 0.2109 mL | 0.4218 mL | 1.0546 mL |
(4-Boc-aminophenyl)boronic acid Related Classifications
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