Copper-Catalyzed Three-Component Reactions of α-Ketoaldehyde, 1,3-Dicarbonyl Compound, and Organic Boronic Acid in Water: A Route to 1,4-Diketones

  • J Org Chem. 2021 Jul 16;86(14):9914-9923. doi: 10.1021/acs.joc.1c01100.
Qi Xia  1 ,  Xiang Li  1 ,  Xi Fu  1 ,  Yaxuan Zhou  1 ,  Yanqing Peng  1 ,  Jiayi Wang  1 ,  Gonghua Song  1
Affiliations
  • 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
PMID: 34181415 DOI: 10.1021/acs.joc.1c01100
Abstract

A novel three-component reaction of α-ketoaldehydes, 1,3-dicarbonyl compounds, and organic boronic acids catalyzed by CuO in water has been developed to give a wide range of products containing 1,3/1,4-diketones. The method has some advantages such as the use of readily available starting Materials, wide substrate scopes, excellent yields, gram-scale synthesis, and mild reaction conditions.

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