1. Academic Validation
  2. Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

  • Hypertension. 2021 Sep;78(3):647-660. doi: 10.1161/HYPERTENSIONAHA.121.17177.
Yuhao Zhang  # 1 Sheng-An Su  # 1 Wudi Li 1 Yuankun Ma 1 Jian Shen 1 Yaping Wang 2 Yimin Shen 1 Jian Chen 1 Yongli Ji 1 Yao Xie 1 Hong Ma 1 Meixiang Xiang 1
Affiliations

Affiliations

  • 1 From the Department of Cardiology (Y.Z., S.-a.S., W.L., Y.M., J.S., Y.S., J.C., Y.J., Y.X., H.M., M.X.), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • 2 Department of Endocrinology (Y.W.), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • # Contributed equally.
Abstract

[Figure: see text].

Keywords

calcineurin; calpain; fibrosis; homeostasis; mechanotransduction.

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