2. Academic Validation
  3. The role of MMP-14 in ovarian cancer: a systematic review

The role of MMP-14 in ovarian cancer: a systematic review

  • J Ovarian Res. 2021 Aug 3;14(1):101. doi: 10.1186/s13048-021-00852-7.
M Caroline Vos 1,  Anneke A M van der Wurff 2,  Toin H van Kuppevelt 3,  Leon F A G Massuger 4
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynaecology, Elisabeth-Tweesteden Hospital, PO Box 90151, 5000 LC, Tilburg, the Netherlands. [email protected].
  • 2 Department of Pathology, Elisabeth-Tweesteden Hospital, PO Box 90151, 5000 LC, Tilburg, the Netherlands.
  • 3 Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.
  • 4 Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.
PMID: 34344453 DOI: 10.1186/s13048-021-00852-7
Abstract

Aim: In order to evaluate the role of MMP-14 in ovarian Cancer, a systematic review was conducted.

Methods: In March 2020, a search in Pubmed was performed with MMP-14 and ovarian Cancer as search terms. After exclusion of the references not on MMP-14 or ovarian Cancer or not in English, the studies found were classified into two categories: basic research and clinicopathological research.

Results: In total, 94 references were found of which 33 were excluded. Two additional articles were found in the reference lists of the included studies. Based on the full texts, another 4 were excluded. Eventually, 59 studies were included in the review, 32 on basic research and 19 on clinicopathological research. 8 studies fell in both categories. The basic research studies show that MMP-14 plays an important role in ovarian Cancer in the processes of proliferation, invasion, angiogenesis and metastasis. In clinocopathological research, MMP-14 expression is found in most tumours with characteristics of poor prognosis but this immunohistochemical MMP-14 determination does not seem to be an independent predictor of prognosis.

Conclusions: From this systematic review of the literature concerning MMP-14 in ovarian Cancer it becomes clear that MMP-14 plays various important roles in the pathophysiology of ovarian Cancer. The exact translation of these roles in the pathophysiology to the importance of MMP-14 in clinicopathological research in ovarian Cancer and possible therapeutic role of anti-MMP-14 agents needs further elucidation.

Keywords

Cancer pathophysiology; Immunohistochemistry; MMP-14; Ovarian cancer; Review.

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