2. Academic Validation
  3. Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis

Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis

  • Phytochemistry. 2021 Nov;191:112910. doi: 10.1016/j.phytochem.2021.112910.
Mengsha Wei 1,  Peng Zhou 1,  Liping Huang 1,  Jie Yin 1,  Qin Li 1,  Chong Dai 1,  Jianping Wang 1,  Lianghu Gu 2,  Qingyi Tong 3,  Hucheng Zhu 4,  Yonghui Zhang 5
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 2 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
  • 3 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
  • 4 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
  • 5 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
PMID: 34481345 DOI: 10.1016/j.phytochem.2021.112910
Abstract

Ten sesterterpenoids, including eight undescribed ones named spectanoids A-H and two known analogs, were obtained from Aspergillus spectabilis. Their structures, including absolute configurations, were determined based on HRESIMS, NMR, ECD calculations and single-crystal X-ray diffraction analyses. Spectanoids A-G are tricyclic sesterterpenoids with an unusual 5/12/5 ring system, while spectanoid H possesses a 5/8/6/5 ring system. All of these compounds were evaluated for their cytotoxic activities against three human Cancer cells, and spectanoid A, spectanoid C and spectanoid F exhibited moderate cytotoxic activities with IC50 values ranging from 12.1 to 26.1 μM.

Keywords

Aspergillaceae; Aspergillus spectabilis; Cytotoxic activities; Sesterterpenoids.

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