2. Academic Validation
  3. Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from Globimetula braunii Leaf

Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from Globimetula braunii Leaf

  • Molecules. 2021 Oct 28;26(21):6528. doi: 10.3390/molecules26216528.
Ayodeji Oluwabunmi Oriola 1,  Adetunji Joseph Aladesanmi 2,  Thomas Oyebode Idowu 3,  Florence O Akinwumi 4,  Efere Martins Obuotor 5,  Temilolu Idowu 6,  Adebola Omowunmi Oyedeji 1
Affiliations

Affiliations

  • 1 Department of Chemical and Physical Sciences, Faculty of Natural Sciences, Walter Sisulu University, Mthatha 5099, South Africa.
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220005, Nigeria.
  • 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220005, Nigeria.
  • 4 Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220005, Nigeria.
  • 5 Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife 220005, Nigeria.
  • 6 Department of Chemistry, Parkers Building, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
PMID: 34770937 DOI: 10.3390/molecules26216528
Abstract

Globimetula braunii is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst Others. We report the isolation and characterization of eight compounds with their antioxidant and antimicrobial activities. The air-dried powdered leaf was macerated in EtOH/H20 (4:1). The extract was solvent-partitioned into n-hexane, EtOAc, n-BuOH and aqueous fractions. The fractions were screened for their antioxidant properties, using DPPH, FRAP, TAC and FIC assays. Antimicrobial analysis was performed using the micro-broth dilution method. The active EtOAc fraction was purified for its putative compounds on a repeated silica gel column chromatography monitored with TLC-bioautography. The isolated compounds were characterized using spectroscopic methods of UV, FT-IR, NMR and MS. Eight compounds (1-8) were isolated and characterized as 13,27-cycloursane (1), phyllanthone (2), globraunone (3), three phenolics: methyl 3,5-dihydroxy-4-methoxybenzoate (4), methyl 3-methyl-4-hydroxybenzoate (5) and guaiacol (6), as well as two phenol derivatives: 4-formaldehyde phenone (7) and 6-methoxy-2H-inden-5-ol (8). The study identified 4 and 6 as natural antioxidant compounds with potential as antimicrobial agents.

Keywords

Globimetula braunii; Loranthaceae; antimicrobial; antioxidant; phenolics; ursane-type triterpenes.

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