2. Academic Validation
  3. The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

  • Arthritis Res Ther. 2021 Nov 25;23(1):288. doi: 10.1186/s13075-021-02678-6.
Bei Xu 1,  Guanhua Xu 1,  Ye Yu 1,  Jin Lin 2
Affiliations

Affiliations

  • 1 Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, #79 Qingchun Road, Hangzhou, Zhejiang Province, People's Republic of China, 310003.
  • 2 Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, #79 Qingchun Road, Hangzhou, Zhejiang Province, People's Republic of China, 310003. [email protected].
PMID: 34819148 DOI: 10.1186/s13075-021-02678-6
Abstract

Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into MicroRNA (miRNAs) in PAH and SSc. This growth of knowledge has well-illustrated the complexity of MicroRNA (miRNA)-based regulation of gene expression in PAH. However, few miRNA-related SSc-PAH were elucidated. This review firstly discusses the role of transforming growth factor-beta (TGF-β) signaling and bone morphogenetic protein receptor type II (BMPR2) in PAH and SSc. Secondly, the miRNAs relating to TGF-β and BMPR2 signaling pathways in PAH and SSc or merely PAH were subsequently summarized. Finally, future studies might develop early diagnostic biomarkers and target-oriented therapeutic strategies for SSc-PAH and PAH treatment.

Keywords

Pulmonary arterial hypertension; Systemic sclerosis; miRNAs.

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