2. Academic Validation
  3. Macrolides from rare actinomycetes: Structures and bioactivities

Macrolides from rare actinomycetes: Structures and bioactivities

  • Int J Antimicrob Agents. 2022 Feb;59(2):106523. doi: 10.1016/j.ijantimicag.2022.106523.
Ammar A Al-Fadhli 1,  Michael D Threadgill 2,  Faez Mohammed 3,  Paul Sibley 4,  Wadie Al-Ariqi 5,  Ifat Parveen 6
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science, Sana'a University, Sana'a, Republic of Yemen; Institute of Biological, Environmental & Rural Sciences (IBERS), Aberystwyth University, Aberystwyth SY23 3DA, United Kingdom. Electronic address: [email protected].
  • 2 Institute of Biological, Environmental & Rural Sciences (IBERS), Aberystwyth University, Aberystwyth SY23 3DA, United Kingdom; Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
  • 3 School of Environmental Sciences, University of Guelph, 50 Stone Road E, Guelph, ON, N1G 2W1, Canada; Faculty of Applied Science-Arhab, Sana'a University, Sana'a, Yemen. Electronic address: [email protected].
  • 4 School of Environmental Sciences, University of Guelph, 50 Stone Road E, Guelph, ON, N1G 2W1, Canada.
  • 5 Department of Chemistry, Faculty of Science, Sana'a University, Sana'a, Republic of Yemen.
  • 6 Institute of Biological, Environmental & Rural Sciences (IBERS), Aberystwyth University, Aberystwyth SY23 3DA, United Kingdom.
PMID: 35041941 DOI: 10.1016/j.ijantimicag.2022.106523
Abstract

Rare actinomycetes are a source of numerous diverse, biologically active secondary metabolites, including macrolides, which have been shown to display several Antibiotic activities. The bioactivities and representative structures of 26 groups of macrolides from rare actinomycetes are presented in this review. The most interesting groups, with a wide range of biological activities, are ammocidins, bafilomycins, neomaclafungins, rosaramicins, spinosyns, and tiacumicins. Most macrolides are from the genus, Micromonospora, with smaller contributions from genera such as Saccharothrix, Amycolatopsis, Nocardiopsis and Catenulispora. These macrolides display unique cytotoxic, Antibacterial, Antifungal, antimicrobial, insecticidal, anti-trypanosomal, antimalarial, antiprotozoal, antimycobacterial and anti-herpetic activity. Considering their bioactivities and diverse structures, macrolides from rare actinomycetes warrant further investigation for future applications in medicine. This work highlights the bioactivities and structures of important classes of macrolides from rare actinomycetes that are already marketed or could be used in medicine in the future.

Keywords

Antibacterial, Antifungal, Antimicrobial; Cytotoxic; Macrolide; Rare actinomycetes.

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