2. Academic Validation
  3. Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

  • Front Bioeng Biotechnol. 2022 Feb 21;10:796820. doi: 10.3389/fbioe.2022.796820.
Zhu Yu 1 2,  Wenlong Cao 1 2,  Chuangye Han 3,  Zhen Wang 1 2,  Yue Qiu 1 2,  Jiancheng Wang 1 2,  Mengda Wei 1 2,  Junfu Wang 1 2,  Siwen Zhang 1 2,  Senfeng Liu 1,  Shutian Mo 2,  Junqiang Chen 1 2
Affiliations

Affiliations

  • 1 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • 2 Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, Nanning, China.
  • 3 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
PMID: 35265591 DOI: 10.3389/fbioe.2022.796820
Abstract

In recent years, sonodynamic therapy (SDT) has been widely developed for Cancer research as a promising non-invasive therapeutic strategy. Here, we synthesized zeolitic imidazole frameworks-8 (ZIF-8) and utilized its properties to encapsulate hydrophobic Chlorin e6 (Ce6) and hydrophilic tirapazamine (TPZ) for a synergistic sonodynamic chemotherapy, which was also accompanied by the modification of cytomembrane of gastric Cancer (GC) cells. Thus, we enabled the biomimetic property to achieve targeted delivery. Ce6-mediated SDT, in combination with ultrasound irradiation, could target the release of Reactive Oxygen Species (ROS) to aggravate further hypoxia and activate TPZ. Combining these effects could induce the Pyroptosis of GC cells and play the anti-tumor function, which could provide a potential therapeutic method for Cancer therapy.

Keywords

ZIF-8; chemotherapy; gastric cancer; pyroptosis; sonodynamic therapy.

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