1. Academic Validation
  2. Xanthatin inhibits non-small cell lung cancer proliferation by breaking the redox balance

Xanthatin inhibits non-small cell lung cancer proliferation by breaking the redox balance

  • Drug Dev Res. 2022 Aug;83(5):1176-1189. doi: 10.1002/ddr.21941.
Yanbo Xie 1 Xueyu Zhu 1 Ping Liu 2 Yunxiao Liu 2 Yadi Geng 1 3 Lei Zhang 1 3 2
Affiliations

Affiliations

  • 1 Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
  • 2 Institute of Clinical Pharmacology, Anhui Medical University, Hefei, Anhui, China.
  • 3 Department of Pharmacy, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Abstract

Lung Cancer is the Cancer with the highest mortality, and non-small cell lung Cancer (NSCLC) accounts for more than 80%. Tumor cells often have high Reactive Oxygen Species (ROS) and antioxidant capacity. Redox balance is very important for tumor. The decline of antioxidant capacity and excessive ROS will induce the death of tumor cells. Destroying the redox balance of tumor cells is a promising tumor treatment strategy. Xanthatin is an active sesquiterpene lactone isolated from Xanthium strumarium L. We observed that xanthatin induced the up regulation of mitochondrial ROS and mitochondrial damage. Meanwhile, our results showed that xanthatin could inhibit system xc - and reduce glutathione (GSH) synthesis. Antioxidant GSH and N-acetyl- l-cysteine (NAC) significantly reversed cell proliferation inhibition and Apoptosis induced by xanthatin. β-Mercaptoethanol (β-ME) which can avoid inhibition of system xc - can also reverse the inhibition of cell proliferation induced by xanthatin, si-SLC7A11 was the opposite. Based on these results, we believe that the inhibition of xanthatin on the proliferation of NSCLC cells may be related to breaking the intracellular redox balance. Our data suggest that xanthatin is a promising antitumor candidate for the treatment of NSCLC.

Keywords

GSH; NSCLC; redox balance; system xc−; xanthatin.

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