2. Academic Validation
  3. Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities

Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities

  • RSC Adv. 2018 Oct 15;8(62):35374-35385. doi: 10.1039/c8ra07549b.
Lanlan Ge 1 2 3,  Haoqiang Wan 1 4,  Shuming Tang 5,  Haixia Chen 5,  Jiemei Li 1 4,  Keda Zhang 1,  Boping Zhou 1,  Jia Fei 3,  Shiping Wu 2,  Xiaobin Zeng 1 4
Affiliations

Affiliations

  • 1 Center Lab of Longhua Branch, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University Shenzhen 518120 Guangdong Province China [email protected] +86-755-28100877 +86-755-27745118.
  • 2 Department of Infectious Disease, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University Shenzhen 518120 Guangdong Province China [email protected].
  • 3 Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University Guangzhou 510632 Guangdong Province China.
  • 4 Department of Pathology (Longhua Branch), Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University Shenzhen 518120 Guangdong Province China.
  • 5 Laboratory Department of Longhua Branch, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University Shenzhen 518120 Guangdong Province China.
PMID: 35547940 DOI: 10.1039/c8ra07549b
Abstract

Lonicera japonica Thunb., possesses Antiviral and hepatoprotective activities, and is widely used as a health food and in cosmetics. However, its major constituents, caffeoylquinic acid derivatives, and their anti-HBV activity were lacking systematic research. In this study, four novel caffeoylquinic acids, five simple caffeic acids and fourteen known caffeoylquinic acids are isolated and identified from L. japonica. Most caffeoylquinic acids inhibited HBsAg and HBeAg secretion, and HBV DNA replication. In particular, 100 μg ml-1 monocaffeoylquinic acid 9 inhibits HBsAg and HBeAg secretion, and HBV DNA replication by 83.82, 70.76 and 39.36% compared to the control. Unfortunately, 50 μg ml-1 tricaffeoylquinic acid 23 promotes HBsAg and HBeAg secretion, and HBV DNA replication by 172.39, 9.92 and 55.40%. Finally, structure-activity relationships reveal that caffeoylquinic acids containing a caffeoyl group have better inhibitory activities. The results indicate that caffeoylquinic acids from L. japonica could serve as anti-HBV agents for functional food or medicinal use.

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