2. Academic Validation
  3. Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

  • Mucosal Immunol. 2022 May;15(5):908-926. doi: 10.1038/s41385-022-00524-9.
Aurélien Trompette 1,  Julie Pernot 2,  Olaf Perdijk 3,  Rayed Ali A Alqahtani 4,  Jaime Santo Domingo 5,  Dolores Camacho-Muñoz 4,  Nicholas C Wong 6,  Alexandra C Kendall 4,  Andreas Wiederkehr 5,  Laurent P Nicod 7,  Anna Nicolaou 4,  Christophe von Garnier 2,  Niki D J Ubags 2,  Benjamin J Marsland 8
Affiliations

Affiliations

  • 1 Division of Pulmonary Medicine, Department of Medicine, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland. [email protected].
  • 2 Division of Pulmonary Medicine, Department of Medicine, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
  • 3 Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
  • 4 Laboratory for Lipidomics and Lipid Biology, University of Manchester, Division of Pharmacy and Optometry, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.
  • 5 Nestlé Institute of Health, EPFL innovation Park, Lausanne, Switzerland.
  • 6 Monash Bioinformatics Platform, Monash University, Clayton, VIC, Australia.
  • 7 Pneumologie, Clinic Cecil from Hirslanden, Lausanne, Switzerland.
  • 8 Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia. [email protected].
PMID: 35672452 DOI: 10.1038/s41385-022-00524-9
Abstract

Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic disorders, for example, food allergies and asthma. Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation, we report that a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity. The gut-skin axis underpins this phenomenon through SCFA production, particularly butyrate, which strengthens skin barrier function by altering Mitochondrial Metabolism of epidermal keratinocytes and the production of key structural components. Our results demonstrate that dietary fibre and SCFA improve epidermal barrier integrity, ultimately limiting early allergen sensitization and disease development.The Graphical Abstract was designed using Servier Medical Art images ( https://smart.servier.com ).

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-15534
    99.0%, Mitochondrial Membrane Potential Probe