2. Academic Validation
  3. 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway

3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway

  • J Asian Nat Prod Res. 2023 Apr;25(4):387-402. doi: 10.1080/10286020.2022.2069565.
Yun-Ting Wang 1 2,  Han Wang 2,  Wu-Jiang Ren 2,  Xue-Ling Dai 1,  Qing Huo 2,  Shuo Wang 3,  Ya-Xuan Sun 1
Affiliations

Affiliations

  • 1 Beijing Key Laboratory of Bioactive Substances and Functional Foods, Institute of Functional Food Science and Technology, Beijing Union University, Beijing 100023, China.
  • 2 Department of Food Science, School of Biochemical Engineering, Beijing Union University, Beijing 100191, China.
  • 3 Department of Food Science, Nankai University School of Medicine, Tianjing 300350, China.
PMID: 35672874 DOI: 10.1080/10286020.2022.2069565
Abstract

The aim of this study is to explore the effect and mechanism of 3,6'-disinapoylsucrose (DISS) on an Alzheimer's disease (AD) mice model induced by APPswe695 lentivirus (LV) and intraperitoneal injection of lipopolysaccharide (LPS). The results show that DISS improves cognitive ability, decreases the levels of IL-2, IL-6, IL-1β, and TNF-α, reduces the expression of NF-κB p65, and alleviates Aβ deposition and nerve cell damage. DISS can regulate tyrosine kinase B (TrkB)/brain-derived neurotrophic factor (BDNF) signaling in the hippocampus. In summary, DISS can significantly alleviate neuroinflammation, spatial learning and memory disorders in AD model mice.

Keywords

Alzheimer's disease; BDNF; LPS; TrkB; neuroinflammation.

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