Cat. No.: HY-N1414

(E)-3',6-Disinapoylsucrose

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(E)-3',6-Disinapoylsucrose is an orally active, blood-brain barrier permeable neuroprotective agent that inhibits Aβ protein aggregation. (E)-3',6-Disinapoylsucrose exerts anxiolytic, anti-inflammatory and cognitive-enhancing effects. (E)-3',6-Disinapoylsucrose regulates the TrkB/BDNF signaling pathway, inhibits the expression of NF-κB p65, reduces pro-inflammatory cytokine levels, and alleviates neuronal damage. (E)-3',6-Disinapoylsucrose also enhances the functions of central 5-HT and noradrenergic systems, thereby improving spatial learning and memory abilities and reducing anxiety-like behaviors. (E)-3',6-Disinapoylsucrose can be used for the research of related diseases such as Alzheimer's disease, depression, memory impairment and anxiety disorder.

For research use only. We do not sell to patients.

Purity: 99.59%
CAS No.: 139891-98-8
Formula: C₃₄H₄₂O₁₉
Molecular Weight:754.69

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

(E)-3',6-Disinapoylsucrose Chemical Structure

CAS No.: 139891-98-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Trk Receptor Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	21.05 μM Compound: 4	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]
BV-2	IC₅₀	37.15 μM Compound: 4	Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay	[PMID: 25466198]
HCT-15	IC₅₀	17.2 μM Compound: 4	Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]
SK-MEL-2	IC₅₀	14.15 μM Compound: 4	Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]
SK-OV-3	IC₅₀	16.69 μM Compound: 4	Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 25466198]

In Vivo

(E)-3',6-Disinapoylsucrose (20 mg/kg; p.o.; 4 weeks) protects SH-SY5Y cells against H₂O₂-induced toxicity and upregulates the expression of CREB and BDNF in cells in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 139891-98-8
Appearance Solid
Molecular Weight 754.69
Formula C₃₄H₄₂O₁₉
Color White to yellow
SMILES

O[C@H]([C@H]([C@@H]([C@@H](COC(/C=C/C1=CC(OC)=C(O)C(OC)=C1)=O)O2)O)O)[C@H]2O[C@@]3(CO)[C@H]([C@@H]([C@@H](CO)O3)O)OC(/C=C/C4=CC(OC)=C(O)C(OC)=C4)=O
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (66.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3250 mL

6.6252 mL

13.2505 mL

5 mM

0.2650 mL

1.3250 mL

2.6501 mL

10 mM

0.1325 mL

0.6625 mL

1.3250 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang YT, et al. 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway. J Asian Nat Prod Res. 2023;25(4):387-402. [Content Brief]

[2]. Chen Y, et al. An LC‐MS/MS method for determination of 3, 6′‐disinapoylsucrose in rat plasma and its application to a pharmacokinetic study[J]. Biomedical Chromatography, 2009, 23(12): 1326-1332.

[3]. Zhang J, et al. Anxiolytic effects, metabolism and plasma pharmacokinetics of 3, 6' -disinapoylsucrose. Biomed Pharmacother. 2022;149:112913. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3250 mL	6.6252 mL	13.2505 mL	33.1262 mL
	5 mM	0.2650 mL	1.3250 mL	2.6501 mL	6.6252 mL
	10 mM	0.1325 mL	0.6625 mL	1.3250 mL	3.3126 mL
	15 mM	0.0883 mL	0.4417 mL	0.8834 mL	2.2084 mL
	20 mM	0.0663 mL	0.3313 mL	0.6625 mL	1.6563 mL
	25 mM	0.0530 mL	0.2650 mL	0.5300 mL	1.3250 mL
	30 mM	0.0442 mL	0.2208 mL	0.4417 mL	1.1042 mL
	40 mM	0.0331 mL	0.1656 mL	0.3313 mL	0.8282 mL
	50 mM	0.0265 mL	0.1325 mL	0.2650 mL	0.6625 mL
	60 mM	0.0221 mL	0.1104 mL	0.2208 mL	0.5521 mL

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(E)-3',6-Disinapoylsucrose

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All Trk Receptor Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(E)-3',6-Disinapoylsucrose Related Classifications

HY-N1414 Related Classifications