139891-98-8
Chemical Structure
(E)-3',6-Disinapoylsucrose
- CAS No.: 139891-98-8
- Formula:C34H42O19
- Molecular Weight:754.69
IUPAC Name: (2S,3S,4R,5R)-4-hydroxy-2,5-bis(hydroxymethyl)-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((E)-3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-3-yl (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)acrylate
InChIKey: FHIJMQWMMZEFBL-OPSYHMPNSA-N
SMILES: O[C@H]([C@H]([C@@H]([C@@H](COC(/C=C/C1=CC(OC)=C(O)C(OC)=C1)=O)O2)O)O)[C@H]2O[C@@]3(CO)[C@H]([C@@H]([C@@H](CO)O3)O)OC(/C=C/C4=CC(OC)=C(O)C(OC)=C4)=O
Biological Activity: (E)-3',6-Disinapoylsucrose is an orally active, blood-brain barrier permeable neuroprotective agent that inhibits Aβ protein aggregation. (E)-3',6-Disinapoylsucrose exerts anxiolytic, anti-inflammatory and cognitive-enhancing effects. (E)-3',6-Disinapoylsucrose regulates the TrkB/BDNF signaling pathway, inhibits the expression of NF-κB p65, reduces pro-inflammatory cytokine levels, and alleviates neuronal damage. (E)-3',6-Disinapoylsucrose also enhances the functions of central 5-HT and noradrenergic systems, thereby improving spatial learning and memory abilities and reducing anxiety-like behaviors. (E)-3',6-Disinapoylsucrose can be used for the research of related diseases such as Alzheimer's disease, depression, memory impairment and anxiety disorder[1][2][3].
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(E)-3',6-Disinapoylsucrose | 99.59% | (E)-3',6-Disinapoylsucrose is an orally active, blood-brain barrier permeable neuroprotective agent that inhibits Aβ protein aggregation. (E)-3',6-Disinapoylsucrose exerts anxiolytic, anti-inflammatory and cognitive-enhancing effects. (E)-3',6-Disinapoylsucrose regulates the TrkB/BDNF signaling pathway, inhibits the expression of NF-κB p65, reduces pro-inflammatory cytokine levels, and alleviates neuronal damage. (E)-3',6-Disinapoylsucrose also enhances the functions of central 5-HT and noradrenergic systems, thereby improving spatial learning and memory abilities and reducing anxiety-like behaviors. (E)-3',6-Disinapoylsucrose can be used for the research of related diseases such as Alzheimer's disease, depression, memory impairment and anxiety disorder. | ||||||||||||||||||||
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(E)-3',6-Disinapoylsucrose (Standard) | ≥98% | (E)-3',6-Disinapoylsucrose (Standard) is the analytical standard of (E)-3',6-Disinapoylsucrose. This product is intended for research and analytical applications. (E)-3',6-Disinapoylsucrose, the index component of Yuanzhi (Polygala tenuifolia Willd), possesses potent antioxidant activity and antidepressant effect. | ||||||||||||||||||||
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References
- [1]. Wang YT, et al. 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway. J Asian Nat Prod Res. 2023;25(4):387-402. [Content Brief]
- [2]. Chen Y, et al. An LC‐MS/MS method for determination of 3, 6′‐disinapoylsucrose in rat plasma and its application to a pharmacokinetic study[J]. Biomedical Chromatography, 2009, 23(12): 1326-1332.
- [3]. Zhang J, et al. Anxiolytic effects, metabolism and plasma pharmacokinetics of 3, 6' -disinapoylsucrose. Biomed Pharmacother. 2022;149:112913. [Content Brief]
