3′,6-Disinapoylsucrose
Based on 2 publication(s) in Google Scholar
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway.
For research use only. We do not sell to patients.
- Purity: 98.88%
- CAS No.: 76656-80-9
- Formula: C34H42O19
- Molecular Weight:754.69
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 3′,6-Disinapoylsucrose
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
21.05 μM
Compound: 4
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Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
| BV-2 | IC50 |
37.15 μM
Compound: 4
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Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay
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[PMID: 25466198] |
| HCT-15 | IC50 |
17.2 μM
Compound: 4
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Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
| SK-MEL-2 | IC50 |
14.15 μM
Compound: 4
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Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
| SK-OV-3 | IC50 |
16.69 μM
Compound: 4
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Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
Chemical Information
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CAS No. 76656-80-9
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Appearance Solid
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Molecular Weight 754.69
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Formula C34H42O19
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Color Off-white to light yellow
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SMILES
OC[C@@]1([C@H]([C@@H]([C@H](O1)CO)O)OC(/C=C/C2=CC(OC)=C(C(OC)=C2)O)=O)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)COC(/C=C/C4=CC(OC)=C(C(OC)=C4)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
Solvent & Solubility
DMSO : 100 mg/mL (132.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.31 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.31 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jiaqi Yuan, et al. 3,6'-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice. J Neurophysiol. 2023 Nov 1;130(5):1174-1182. [Content Brief]
[2]. Jie Zhang, et al. Anxiolytic effects, metabolism and plasma pharmacokinetics of 3, 6' -disinapoylsucrose. Biomed Pharmacother. 2022 May:149:112913. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3250 mL | 6.6252 mL | 13.2505 mL | 33.1262 mL |
| 5 mM | 0.2650 mL | 1.3250 mL | 2.6501 mL | 6.6252 mL | |
| 10 mM | 0.1325 mL | 0.6625 mL | 1.3250 mL | 3.3126 mL | |
| 15 mM | 0.0883 mL | 0.4417 mL | 0.8834 mL | 2.2084 mL | |
| 20 mM | 0.0663 mL | 0.3313 mL | 0.6625 mL | 1.6563 mL | |
| 25 mM | 0.0530 mL | 0.2650 mL | 0.5300 mL | 1.3250 mL | |
| 30 mM | 0.0442 mL | 0.2208 mL | 0.4417 mL | 1.1042 mL | |
| 40 mM | 0.0331 mL | 0.1656 mL | 0.3313 mL | 0.8282 mL | |
| 50 mM | 0.0265 mL | 0.1325 mL | 0.2650 mL | 0.6625 mL | |
| 60 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5521 mL | |
| 80 mM | 0.0166 mL | 0.0828 mL | 0.1656 mL | 0.4141 mL | |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1325 mL | 0.3313 mL |
3′,6-Disinapoylsucrose Related Classifications
HY-N1414A Related Classifications
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