2. Academic Validation
  3. Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity

Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity

  • Fitoterapia. 2022 Sep:161:105233. doi: 10.1016/j.fitote.2022.105233.
Yuting Zhang 1,  Xing Peng 1,  Zhejun Sun 1,  Chen Hu 1,  Huihao Zhou 1,  Jun Xu 1,  Qiong Gu 2
Affiliations

Affiliations

  • 1 Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
  • 2 Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: [email protected].
PMID: 35690188 DOI: 10.1016/j.fitote.2022.105233
Abstract

The phytochemical investigation on Atractylodes chinensis afforded 15 polyacetylenes 1-15 and one meroterpenoid 16. Of the 16 isolates, compounds 4 and 9 are new ones, and compounds 8 and 16 are first reported from nature. In addition, the relative configuration of 1 and the available NMR data of compounds 1, 8, and 16 were first provided. Their structures were elucidated by extensive analysis of MS, UV, IR, and NMR spectroscopic data. Besides, all isolated compounds were evaluated for their effects on RANKL-induced osteoclastogenesis in BMMs. Among them, polyacetylenes 12-14 showed potent inhibitory activity with IC50 values of 0.67 ± 0.05 μM, 0.72 ± 0.31 μM, and 2.40 ± 0.41 μM, respectively. The current work demonstrates the polyacetylenes are the main active constituents of A. chinensis against osteoclastogenesis.

Keywords

Atractylodes chinensis; Meroterpenoid; Osteoporosis; Polyacetylene.

Figures
Products