2. Academic Validation
  3. Molecular-Targeted Therapy of Pediatric Acute Myeloid Leukemia

Molecular-Targeted Therapy of Pediatric Acute Myeloid Leukemia

  • Molecules. 2022 Jun 18;27(12):3911. doi: 10.3390/molecules27123911.
Piotr Obszański 1,  Anna Kozłowska 1,  Jakub Wańcowiat 2,  Julia Twardowska 2,  Monika Lejman 3,  Joanna Zawitkowska 4
Affiliations

Affiliations

  • 1 Student Scientific Society, Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Gębali 6, 20-093 Lublin, Poland.
  • 2 Student Scientific Society, Laboratory of Genetic Diagnostics, Medical University of Lublin, Gębali 6, 20-093 Lublin, Poland.
  • 3 Laboratory of Genetic Diagnostics, Medical University of Lublin, Gębali 6, 20-093 Lublin, Poland.
  • 4 Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Gębali 6, 20-093 Lublin, Poland.
PMID: 35745032 DOI: 10.3390/molecules27123911
Abstract

Acute myeloid leukemia (AML) accounts for approximately 15-20% of all childhood leukemia cases. The overall survival of children with acute myeloid leukemia does not exceed 82%, and the 5-year event-free survival rates range from 46% to 69%. Such suboptimal outcomes are the result of numerous mutations and epigenetic changes occurring in this disease that adversely affect the susceptibility to treatment and relapse rate. We describe various molecular-targeted therapies that have been developed in recent years to meet these challenges and were or are currently being studied in clinical trials. First introduced in adult AML, novel forms of treatment are slowly beginning to change the therapeutic approach to pediatric AML. Despite promising results of clinical trials investigating new drugs, further clinical studies involving greater numbers of pediatric patients are still needed to improve the outcomes in childhood AML.

Keywords

acute myeloid leukemia; pediatric AML; target therapies.

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