2. Academic Validation
  3. CD160 Promotes NK Cell Functions by Upregulating Glucose Metabolism and Negatively Correlates With HIV Disease Progression

CD160 Promotes NK Cell Functions by Upregulating Glucose Metabolism and Negatively Correlates With HIV Disease Progression

  • Front Immunol. 2022 Aug 19:13:854432. doi: 10.3389/fimmu.2022.854432.
Zheng Sun 1 2 3,  Yidi Li 1 2 3,  Zining Zhang 1 2 3,  Yajing Fu 1 2 3,  Xiaoxu Han 1 2 3,  Qinghai Hu 1 2 3,  Haibo Ding 1 2 3,  Hong Shang 1 2 3 4,  Yongjun Jiang 1 2 3
Affiliations

Affiliations

  • 1 National Health Commission (NHC) Key Laboratory of Acquired Immunodeficiency Syndrome (AIDS) Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • 2 Key Laboratory of Acquired Immunodeficiency Syndrome (AIDS) Immunology, Chinese Academy of Medical Sciences, Shenyang, China.
  • 3 Key Laboratory of Acquired Immunodeficiency Syndrome (AIDS) Immunology of Liaoning Province, Shenyang, China.
  • 4 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
PMID: 36110864 DOI: 10.3389/fimmu.2022.854432
Abstract

Natural killer (NK) cells are crucial for immune responses to viral infections. CD160 is an important NK cell activating receptor, with unknown function in HIV Infection. Here, we found that CD160 expression was reduced on NK cells from HIV-infected individuals and its expression was negatively correlated with HIV disease progression. Further, GLUT1 expression and glucose uptake were higher in CD160+ NK cells, and the results of RNA-seq and flow cytometry demonstrated that CD160 positively regulated glucose metabolism through the PI3K/Akt/mTOR/s6k signaling pathway, thereby enhancing NK cell function. Moreover, we determined that reduced CD160 expression on NK cells could be attributed to the higher plasma levels of TGF-β1 in HIV-infected individuals. Overall, these results highlight the vital role of CD160 in HIV disease progression and regulation of glucose metabolism, indicating a potential target for HIV immunotherapy.

Keywords

CD160; HIV; NK cells; PI3K/AKT/mTOR/s6k signaling pathway; TGF-β1; glucose metabolism.

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