2. Academic Validation
  3. Discovery of endogenous nitroxyl as a new redox player in Arabidopsis thaliana

Discovery of endogenous nitroxyl as a new redox player in Arabidopsis thaliana

  • Nat Plants. 2022 Dec 23. doi: 10.1038/s41477-022-01301-z.
M Arasimowicz-Jelonek 1,  J Floryszak-Wieczorek 2,  S Suarez 3 4,  F Doctorovich 4,  E Sobieszczuk-Nowicka 5,  S Bruce King 6,  G Milczarek 7,  T Rębiś 7,  J Gajewska 3,  P Jagodzik 3,  M Żywicki 8
Affiliations

Affiliations

  • 1 Department of Plant Ecophysiology, Adam Mickiewicz University, Poznań, Poland. [email protected].
  • 2 Department of Plant Physiology, Poznań University of Life Sciences, Poznań, Poland.
  • 3 Department of Plant Ecophysiology, Adam Mickiewicz University, Poznań, Poland.
  • 4 Departamento de Química Inorgánica, Analítica, y Química Física, Universidad de Buenos Aires, INQUIMAE-CONICET, Buenos Aires, Argentina.
  • 5 Department of Plant Physiology, Adam Mickiewicz University, Poznań, Poland.
  • 6 Department of Chemistry, Wake Forest University, Winston-Salem, NC, USA.
  • 7 Poznan University of Technology, Institute of Chemistry and Technical Electrochemistry, Poznan, Poland.
  • 8 Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznań, Poland.
PMID: 36564632 DOI: 10.1038/s41477-022-01301-z
Abstract

Nitroxyl (HNO) is the one-electron reduced and protonated congener of nitric oxide (•NO), owning a distinct chemical profile. Based on real-time detection, we demonstrate that HNO is endogenously formed in Arabidopsis. Senescence and hypoxia induce shifts in the redox balance, triggering HNO decay or formation mediated by non-enzymatic •NO/HNO interconversion with cellular reductants. The stimuli-dependent HNO generation supports or competes with •NO signalling, depending on the local redox environment.

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