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Cimlanod (Synonyms: BMS-986231; CXL-1427)

Cat. No.: HY-118643
Handling Instructions

Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects.

For research use only. We do not sell to patients.

Cimlanod Chemical Structure

Cimlanod Chemical Structure

CAS No. : 1620330-72-4

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Description

Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects[1][2].

Molecular Weight

177.18

Formula

C₅H₇NO₄S

CAS No.

1620330-72-4

SMILES

O=S(C1=CC=C(O1)C)(NO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1410.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6440 mL 28.2199 mL 56.4398 mL
5 mM 1.1288 mL 5.6440 mL 11.2880 mL
10 mM 0.5644 mL 2.8220 mL 5.6440 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (11.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (11.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (11.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CimlanodBMS-986231CXL-1427BMS986231BMS 986231CXL1427CXL 1427OthersHNOdonornitroxylheartfailurecardiovascularvasodilatoryeffectsInhibitorinhibitorinhibit

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Cimlanod
Cat. No.:
HY-118643
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