Discovery of endogenous nitroxyl as a new redox player in Arabidopsis thaliana

  • Nat Plants. 2022 Dec 23. doi: 10.1038/s41477-022-01301-z.
M Arasimowicz-Jelonek  1 ,  J Floryszak-Wieczorek  2 ,  S Suarez  3  4 ,  F Doctorovich  4 ,  E Sobieszczuk-Nowicka  5 ,  S Bruce King  6 ,  G Milczarek  7 ,  T Rębiś  7 ,  J Gajewska  3 ,  P Jagodzik  3 ,  M Żywicki  8
Affiliations
  • 1. Department of Plant Ecophysiology, Adam Mickiewicz University, Poznań, Poland. [email protected].
  • 2. Department of Plant Physiology, Poznań University of Life Sciences, Poznań, Poland.
  • 3. Department of Plant Ecophysiology, Adam Mickiewicz University, Poznań, Poland.
  • 4. Departamento de Química Inorgánica, Analítica, y Química Física, Universidad de Buenos Aires, INQUIMAE-CONICET, Buenos Aires, Argentina.
  • 5. Department of Plant Physiology, Adam Mickiewicz University, Poznań, Poland.
  • 6. Department of Chemistry, Wake Forest University, Winston-Salem, NC, USA.
  • 7. Poznan University of Technology, Institute of Chemistry and Technical Electrochemistry, Poznan, Poland.
  • 8. Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznań, Poland.
PMID: 36564632 DOI: 10.1038/s41477-022-01301-z
Abstract

Nitroxyl (HNO) is the one-electron reduced and protonated congener of nitric oxide (•NO), owning a distinct chemical profile. Based on real-time detection, we demonstrate that HNO is endogenously formed in Arabidopsis. Senescence and hypoxia induce shifts in the redox balance, triggering HNO decay or formation mediated by non-enzymatic •NO/HNO interconversion with cellular reductants. The stimuli-dependent HNO generation supports or competes with •NO signalling, depending on the local redox environment.

Products