1620330-72-4
1620330-72-4
Chemical Structure
Cimlanod
Synonym(s): BMS-986231; CXL-1427
- No. CAS: 1620330-72-4
- Formula:C5H7NO4S
- Molecular Weight:177.18
IUPAC Name: N-hydroxy-5-methylfuran-2-sulfonamide
InChIKey: LIXKIXWSKOENAB-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(O1)C)(NO)=O
Biological Activity: Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod is the prodrug of CXL-1020 (HY-147384)[1][2].
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Cimlanod | 99.82% | Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod is the prodrug of CXL-1020 (HY-147384). | ||||||||||||||||||||
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References
- [1]. Cowart D, et al. A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. J Clin Pharmacol. 2019 May;59(5):717-730. [Content Brief]
- [2]. Felker GM, et al. Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. Eur J Heart Fail. 2019 Aug;21(8):1022-1031. [Content Brief]
