1620330-72-4
Chemical Structure
Cimlanod
Synonym(s): BMS-986231; CXL-1427
- CAS No.: 1620330-72-4
- Formula:C5H7NO4S
- Molecular Weight:177.18
IUPAC Name: N-hydroxy-5-methylfuran-2-sulfonamide
InChIKey: LIXKIXWSKOENAB-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(O1)C)(NO)=O
Biological Activity: Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod is the prodrug of CXL-1020 (HY-147384)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cimlanod | 99.82% | Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod is the prodrug of CXL-1020 (HY-147384). | ||||||||||||||||||||
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Similarity Score 0.70
HY-120990Piloty's acid -
Similarity Score 0.69
HY-W0879195-Methyl-2-furanmethanol -
Similarity Score 0.69
HY-Y0543R5-Methylfurfural (Standard) -
Similarity Score 0.67
HY-W0128132-Acetyl-5-methylfuran -
Similarity Score 0.66
HY-W0058795-Formylfuran-2-carboxylic acid -
Similarity Score 0.66
HY-W0021052,5-Furandicarboxylic acid -
Similarity Score 0.66
HY-W7481932,5-Furandicarboxylic acid-13C6 -
Similarity Score 0.65
HY-762172,5-Furandicarboxaldehyde -
Similarity Score 0.65
HY-101010Methylfurmethide iodide -
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References
- [1]. Cowart D, et al. A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. J Clin Pharmacol. 2019 May;59(5):717-730. [Content Brief]
- [2]. Felker GM, et al. Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. Eur J Heart Fail. 2019 Aug;21(8):1022-1031. [Content Brief]
