2,5-Furandicarboxylic acid

Name: 2,5-Furandicarboxylic acid
Brand: MedChemExpress
SKU: HY-W002105
Rating: 4.5 (1 reviews)

Cat. No.: HY-W002105 Purity: 99.03%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

2,5-Furandicarboxylic acid, detected in human urine, is an important renewable biotechnological building block because it serves as an environmentally friendly substitute for terephthalic acid in the production of polyesters. 2,5-Furandicarboxylic acid can be used as the raw material for various chemical intermediates to synthesize polymers, polyurethanes, thermosetting resins, plasticizers, fungicides, macrocyclic ligands and other products.

For research use only. We do not sell to patients.

2,5-Furandicarboxylic acid Chemical Structure

CAS No. : 3238-40-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2,5-Furandicarboxylic acid:

2,5-Furandicarboxylic acid (Standard) Get quote

1 Publications Citing Use of MCE 2,5-Furandicarboxylic acid

•Research Square Preprint. 2021 Aug.

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

2,5-Furandicarboxylic acid can be used as the monomer for synthesis of biodegradable polymers such as polyethylene furandicarboxylate (PEF) and polybutylene furandicarboxylate (PBF). 2,5-Furandicarboxylic acid improves the polymers' rigidity, heat resistance and barrier properties, that can be used for food packaging^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

156.09

Formula

C₆H₄O₅

CAS No.

3238-40-2

Appearance

Solid

Color

White to light yellow

SMILES

OC(C1=CC=C(C(O)=O)O1)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (640.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 16.67 mg/mL (106.80 mM; ultrasonic and adjust pH to 12 with H₂O)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4066 mL	32.0328 mL	64.0656 mL
5 mM	1.2813 mL	6.4066 mL	12.8131 mL
10 mM	0.6407 mL	3.2033 mL	6.4066 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (16.02 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (16.02 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (247 KB) HNMR (150 KB) RP-HPLC (258 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Hossain GS, et al. Metabolic Engineering of Raoultella ornithinolytica BF60 for Production of 2,5-Furandicarboxylic Acid from 5-Hydroxymethylfurfural. Appl Environ Microbiol. 2016 Dec 15;83(1):e02312-16. [Content Brief]

[2]. Prasad S, et al. Recent advances in the production of 2, 5-furandicarboxylic acid from biorenewable resources[J]. Materials Science for Energy Technologies, 2023, 6: 502-521.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	6.4066 mL	32.0328 mL	64.0656 mL	160.1640 mL
	5 mM	1.2813 mL	6.4066 mL	12.8131 mL	32.0328 mL
	10 mM	0.6407 mL	3.2033 mL	6.4066 mL	16.0164 mL
	15 mM	0.4271 mL	2.1355 mL	4.2710 mL	10.6776 mL
	20 mM	0.3203 mL	1.6016 mL	3.2033 mL	8.0082 mL
	25 mM	0.2563 mL	1.2813 mL	2.5626 mL	6.4066 mL
	30 mM	0.2136 mL	1.0678 mL	2.1355 mL	5.3388 mL
	40 mM	0.1602 mL	0.8008 mL	1.6016 mL	4.0041 mL
	50 mM	0.1281 mL	0.6407 mL	1.2813 mL	3.2033 mL
	60 mM	0.1068 mL	0.5339 mL	1.0678 mL	2.6694 mL
	80 mM	0.0801 mL	0.4004 mL	0.8008 mL	2.0021 mL
	100 mM	0.0641 mL	0.3203 mL	0.6407 mL	1.6016 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.