2. Academic Validation
  3. Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

  • Biomaterials. 2023 Feb:293:121980. doi: 10.1016/j.biomaterials.2022.121980.
Bowen Zhang 1,  Gan Chen 2,  Xumin Wu 1,  Yunxing Li 3,  Yao Xiao 2,  Jisheng Li 3,  Lijuan He 4,  Yunqiao Li 3,  Sihan Wang 1,  Jiahui Zhao 3,  Chuanli Liu 3,  Hong Zhou 5,  Yanhua Li 6,  Xuetao Pei 7
Affiliations

Affiliations

  • 1 Beijing Institute of Radiation Medicine, Beijing 100850, China; South China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou 510005, China.
  • 2 Institute of Health Service and Transfusion Medicine, Beijing 100850, China.
  • 3 Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • 4 Institute of Health Service and Transfusion Medicine, Beijing 100850, China; South China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou 510005, China.
  • 5 Institute of Health Service and Transfusion Medicine, Beijing 100850, China. Electronic address: [email protected].
  • 6 Beijing Institute of Radiation Medicine, Beijing 100850, China; South China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou 510005, China. Electronic address: [email protected].
  • 7 Beijing Institute of Radiation Medicine, Beijing 100850, China; South China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou 510005, China. Electronic address: [email protected].
PMID: 36580722 DOI: 10.1016/j.biomaterials.2022.121980
Abstract

There is an urgent medical need to develop effective therapies that can ameliorate damage to the radiation-exposed hematopoietic system. Nanozymes with robust antioxidant properties have a therapeutic potential for mitigating radiation-induced hematopoietic injury. However, enhancing nanozyme recruitment to injured tissues in vivo while maintaining their catalytic activity remains a great challenge. Herein, we present the design and preparation of a biomimetic nanoparticle, a mesenchymal stem cell membrane camouflaged Prussian blue nanozyme (PB@MSCM), which exhibits biocompatible surface properties and demonstrates enhanced injury site-targeting towards the irradiated murine bone marrow niche. Notably, the constructed PB@MSCM possessed redox enzyme-mimic catalytic activity and could scavenge overproduced Reactive Oxygen Species in the irradiated bone marrow cells, both in vitro and ex vivo. More importantly, the administration of PB@MSCM significantly mitigated hematopoietic cell Apoptosis and accelerated the regeneration of hematopoietic stem and progenitor cells. Our findings provide a new targeted strategy to improve nanozyme therapy in vivo and mitigate radiation-induced hematopoietic injury.

Keywords

Mesenchymal stem cell membrane; Prussian blue nanozymes; Radiation-induced hematopoietic injury; Reactive oxygen species; Targeting therapy.

Figures
Products