2. Academic Validation
  3. Staphylococcus aureus induces mitophagy to promote its survival within bovine mammary epithelial cells

Staphylococcus aureus induces mitophagy to promote its survival within bovine mammary epithelial cells

  • Vet Microbiol. 2023 May:280:109697. doi: 10.1016/j.vetmic.2023.109697.
Dianwen Xu 1,  Guiqiu Hu 1,  Jianchun Luo 1,  Ji Cheng 1,  Di Wu 1,  Lisha Cheng 1,  Xuejie Huang 1,  Shoupeng Fu 2,  Juxiong Liu 3
Affiliations

Affiliations

  • 1 College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, China.
  • 2 College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, China. Electronic address: [email protected].
  • 3 College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin, China. Electronic address: [email protected].
PMID: 36827937 DOI: 10.1016/j.vetmic.2023.109697
Abstract

Mitophagy occurs in a variety of pathogenic infections. However, the role of Mitophagy in the intracellular survival of Staphylococcus aureus (S.aureus) within bovine mammary epithelial cells (BMECs) and which molecules specifically mediate the induction of Mitophagy remains unclear. Therefore, this study aims to investigate the role and mechanism of Mitophagy in the intracellular survival of S.aureus. Here, we reported that S.aureus induced complete Mitophagy to promote its survival within BMECs. The further mechanistic study showed that S. aureus induced Mitophagy by activating the p38-PINK1-Parkin signaling pathway. These findings expand our knowledge of the intracellular survival mechanism of S.aureus in the host and provide a desirable therapeutic strategy against S.aureus and Other intracellular infections.

Keywords

Bovine mammary epithelial cells; Intracellular infection; Mitophagy; P38-PINK1-Parkin; Staphylococcus aureus.

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