2. Academic Validation
  3. A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration

A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration

  • Bioact Mater. 2022 Nov 29:25:399-414. doi: 10.1016/j.bioactmat.2022.11.004.
Liangyu Wang 1,  Yanyun Pang 2,  Yujing Tang 3,  Xinyu Wang 1,  Daixing Zhang 1,  Xu Zhang 2,  Yingjie Yu 1,  Xiaoping Yang 1 4,  Qing Cai 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
  • 2 School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
  • 3 SINOPEC (Beijing) Research Institute of Chemical Industry Co., Ltd., Beijing, 100013, China.
  • 4 Foshan (Southern China) Institute for New Materials, Foshan, 528200, Guangdong, China.
PMID: 37056250 DOI: 10.1016/j.bioactmat.2022.11.004
Abstract

Natural bone is a composite tissue made of organic and inorganic components, showing piezoelectricity. Whitlockite (WH), which is a natural magnesium-containing calcium phosphate, has attracted great attention in bone formation recently due to its unique piezoelectric property after sintering treatment and sustained release of magnesium ion (Mg2+). Herein, a composite scaffold (denoted as PWH scaffold) composed of piezoelectric WH (PWH) and poly(ε-caprolactone) (PCL) was 3D printed to meet the physiological demands for the regeneration of neuro-vascularized bone tissue, namely, providing endogenous electric field at the defect site. The sustained release of Mg2+ from the PWH scaffold, displaying multiple biological activities, and thus exhibits a strong synergistic effect with the piezoelectricity on inhibiting osteoclast activation, promoting the neurogenic, angiogenic, and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) in vitro. In a rat calvarial defect model, this PWH scaffold is remarkably conducive to efficient neo-bone formation with rich neurogenic and angiogenic expressions. Overall, this study presents the first example of biomimetic piezoelectric scaffold with sustained Mg2+ release for promoting the regeneration of neuro-vascularized bone tissue in vivo, which offers new insights for regenerative medicine.

Keywords

Angiogenic; Bone regeneration; Neurogenic; Osteogenic; Piezoelectricity.

Figures
Products