2. Academic Validation
  3. Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells

Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells

  • RSC Med Chem. 2023 Mar 1;14(4):710-714. doi: 10.1039/d3md00049d.
Timothy L Gialelis 1,  Zifei Wang 2,  Joshua A Homer 2,  Wen-Hsuan Yang 2,  Taemoon Chung 2,  Qingting Hu 2 3,  Christopher J Smedley 1,  Nitin J Pawar 2,  Nitinkumar S Upadhyay 2,  David A Tuveson 2,  Scott K Lyons 2,  Michael J Lukey 2,  John E Moses 2
Affiliations

Affiliations

  • 1 La Trobe Institute for Molecular Science, La Trobe University Melbourne VIC 3086 Australia.
  • 2 Cancer Center, Cold Spring Harbor Laboratory 1 Bungtown Road Cold Spring Harbor NY 11724 USA [email protected] [email protected].
  • 3 Graduate Program in Genetics, Stony Brook University Stony Brook NY 11794 USA.
PMID: 37122543 DOI: 10.1039/d3md00049d
Abstract

A concise semi-synthesis of the Aspidosperma Alkaloids, (-)-jerantinine A and (-)-melodinine P, and derivatives thereof, is reported. The novel compounds were shown to have potent activity against MDA-MB-231 triple-negative breast Cancer cells. Furthermore, unbiased metabolomics and live cell reporter assays reveal (-)-jerantinine A alters cellular redox metabolism and induces oxidative stress that coincides with cell cycle arrest.

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