2. Academic Validation
  3. A new iridoid glucoside from the roots of Morinda officinalis

A new iridoid glucoside from the roots of Morinda officinalis

  • J Asian Nat Prod Res. 2023 Dec;25(12):1223-1228. doi: 10.1080/10286020.2023.2211510.
Le Thi Huyen 1,  Nguyen Thi Hien 1,  Nguyen Viet Duy Anh 2,  Vu Mai Thao 2,  Nguyen Thi Kim Thoa 3,  Nguyen Thi Minh Hang 2
Affiliations

Affiliations

  • 1 VNU University of Science, Vietnam National University, Thanh Xuan, Hanoi 11400, Vietnam.
  • 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi 10072, Vietnam.
  • 3 Faculty of Basic Science, Hanoi University of Mining and Geology, Hanoi 11900, Vietnam.
PMID: 37232117 DOI: 10.1080/10286020.2023.2211510
Abstract

A new iridoid glucoside, moridoside (1), and nine known compounds, asperulosidic acid (2), 6-O-epi-acetylscandoside (3), geniposidic acid (4), 2-hydroxymethylanthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), damnacanthol (7), lucidine-ω-methyl ether (8), 2-hydroxy-1-methoxyanthraquinone (9), and 3,8-dihydroxy-1,2-dimethoxyanthraquinone (10) were isolated from the methanol extract of Morinda officinalis How. roots. Their structural identification was carried out based on the spectroscopic evidence. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in LPS-stimulated RAW264.7 macrophages. Compounds 5-7 significantly inhibited the production of NO with IC50 values of 28.4, 33.6, and 30.5 μM, respectively.

Keywords

Morinda officinalis; Rubiaceae; iridoid; moridoside; nitric oxide.

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