2. Academic Validation
  3. ATAD2 promotes glycolysis and tumor progression in clear cell renal cell carcinoma by regulating the transcriptional activity of c-Myc

ATAD2 promotes glycolysis and tumor progression in clear cell renal cell carcinoma by regulating the transcriptional activity of c-Myc

  • Discov Oncol. 2023 May 26;14(1):79. doi: 10.1007/s12672-023-00696-1.
Zonglong Wu 1,  Liyuan Ge 1,  Yimeng Song 1,  Shaohui Deng 1,  Peichen Duan 1,  Tan Du 1,  Yaqian Wu 1,  Zhanyi Zhang 1,  Xiaofei Hou 1,  Lulin Ma 2,  Shudong Zhang 3
Affiliations

Affiliations

  • 1 Department of Urology, Peking University Third Hospital, Beijing, 100191, P.R. China.
  • 2 Department of Urology, Peking University Third Hospital, Beijing, 100191, P.R. China. [email protected].
  • 3 Department of Urology, Peking University Third Hospital, Beijing, 100191, P.R. China. [email protected].
PMID: 37233956 DOI: 10.1007/s12672-023-00696-1
Abstract

Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urogenital tract. Given that ccRCC is often resistant to radiotherapy and traditional chemotherapy, the clinical treatment of patients with ccRCC remains a challenge. The present study found that ATAD2 was significantly upregulated in ccRCC tissues. In vitro and in vivo experiments showed that the inhibition of ATAD2 expression mitigated the aggressive phenotype of ccRCC. ATAD2 was also associated with glycolysis in ccRCC. Interestingly, we found that ATAD2 could physically interact with c-Myc and promote the expression of its downstream target gene, thereby enhancing the Warburg effect of ccRCC. Overall, our study emphasizes the role of ATAD2 in ccRCC. The targeted expression or functional regulation of ATAD2 could be a promising method to reduce the proliferation and progression of ccRCC.

Keywords

ATAD2; Clear cell renal cell carcinoma; Glycolysis; c-Myc.

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