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BAY-850 

Cat. No.: HY-119254
Handling Instructions

BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.

For research use only. We do not sell to patients.

BAY-850 Chemical Structure

BAY-850 Chemical Structure

CAS No. : 2099142-76-2

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Description

BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.

IC50 & Target

ATAD2[1].

In Vitro

BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

654.24

Formula

C₃₈H₄₄ClN₅O₃

CAS No.

2099142-76-2

SMILES

O=C(N[[email protected]](CC1=CC=C(C#N)C=C1)CN[[email protected]]2CC[[email protected]@H](N)CC2)C3=CC(C4=CC=C(CN[[email protected]@H](C5=CC=C(C)C=C5)C)O4)=C(OC)C=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BAY-850
Cat. No.:
HY-119254
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BAY-850

Cat. No.: HY-119254