2. Academic Validation
  3. Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus

Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus

  • J Nat Prod. 2023 Jun 23;86(6):1606-1614. doi: 10.1021/acs.jnatprod.3c00300.
Jun-Su Zhou 1,  Jia-Ying Yao 2 3,  Yuan Gao 1,  Qun-Fang Liu 1,  Bin Zhou 1 4,  Shi-Jun He 3,  Jin-Xin Zhao 1 4,  Jian-Min Yue 1 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
  • 2 College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, 818 Meiling Avenue, Nanchang, Jiangxi 330004, People's Republic of China.
  • 3 Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, People's Republic of China.
  • 4 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, 198 East Binhai Road, Yantai, Shandong 264117, People's Republic of China.
PMID: 37307145 DOI: 10.1021/acs.jnatprod.3c00300
Abstract

Chemical investigation of the twigs of Cleistanthus sumatranus (Phyllanthaceae) led to the isolation of 10 undescribed Lignans, sumatranins A-J (1-10). Compounds 1-4 are unprecedented furopyran Lignans characterized by a unique 2,3,3a,9a-tetrahydro-4H-furo[2,3-b]chromene heterotricyclic framework. Compounds 9 and 10 are rare 9'-nor-dibenzylbutane Lignans. Structures were established based on analyses of spectroscopic data, X-ray crystallographic data, and experimental ECD spectra. Immunosuppressive assays revealed compounds 3 and 9 displayed moderate inhibitory effects with good selectivity indexes against LPS-induced B lymphocyte proliferation.

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