2. Academic Validation
  3. The NLRP3 inflammasome: contributions to inflammation-related diseases

The NLRP3 inflammasome: contributions to inflammation-related diseases

  • Cell Mol Biol Lett. 2023 Jun 27;28(1):51. doi: 10.1186/s11658-023-00462-9.
Ying Chen # 1,  Xingyan Ye # 2 3,  Germaine Escames # 4 5 6,  Wangrui Lei 2 3,  Xin Zhang 7,  Meng Li 7,  Tong Jing 7,  Yu Yao 2 3,  Zhenye Qiu 2 3,  Zheng Wang 8,  Darío Acuña-Castroviejo 9 10 11,  Yang Yang 12 13
Affiliations

Affiliations

  • 1 Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • 2 Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
  • 3 Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.
  • 4 Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain.
  • 5 Ibs. Granada and CIBERfes, Granada, Spain.
  • 6 UGC of Clinical Laboratories, University San Cecilio's Hospital, Granada, Spain.
  • 7 Department of Cardiology, Affiliated Hospital, Yan'an University, Yan'an, China.
  • 8 Department of Cardiothoracic Surgery, Central Theater Command General Hospital of Chinese People's Liberation Army, Wuhan, China.
  • 9 Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain. [email protected].
  • 10 Ibs. Granada and CIBERfes, Granada, Spain. [email protected].
  • 11 UGC of Clinical Laboratories, University San Cecilio's Hospital, Granada, Spain. [email protected].
  • 12 Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China. [email protected].
  • 13 Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China. [email protected].
  • # Contributed equally.
PMID: 37370025 DOI: 10.1186/s11658-023-00462-9
Abstract

The NOD-like Receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating Caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer's disease, inflammatory bowel disease, and Other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.

Keywords

Inflammatory disease; Innate immunity; NLRP3 inflammasome.

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