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  3. Four New Flavonoid C-Glycosides Isolated from Achyranthes aspera and Their Nitric Oxide Production Inhibitory Activities

Four New Flavonoid C-Glycosides Isolated from Achyranthes aspera and Their Nitric Oxide Production Inhibitory Activities

  • Chem Biodivers. 2023 Aug;20(8):e202300853. doi: 10.1002/cbdv.202300853.
Hoang Thi Tuyet Lan 1,  Nguyen Thi Mai 1,  Bui Thi Mai Anh 1,  Duong Thi Dung 2,  Phan Van Kiem 2 3,  Bui Huu Tai 2 3
Affiliations

Affiliations

  • 1 Faculty of of Basic Sciences, University of Transport and Communications, Cau Giay, Lang Thuong, Dong Da, 10072, Hanoi, Vietnam.
  • 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam.
  • 3 Faculty of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam.
PMID: 37409765 DOI: 10.1002/cbdv.202300853
Abstract

A chemical study of the methanol extract of the aerial parts of Achyranthes aspera led to the isolation of four new flavonoid C-glycosides (1-4) along with eight known analogs (5-12). Their structures were elucidated by a combination of spectroscopic data analysis, HR-ESI-MS, 1D and 2D NMR spectra. All the isolates were evaluated their NO production inhibitory activity in LPS-activated RAW264.7 cells. Compounds 2, 4, and 8-11 showed significant inhibition with IC50 values ranging from 25.06 to 45.25 μM, compared to that of the positive control compound, L-NMMA, IC50 value of 32.24 μM, whereas the remaining compounds were weak inhibitory activity with IC50 values over 100 μM. This is the first report of 7 from Amaranthaceae family, and 11 from the genus Achyranthes.

Keywords

Achyranthes aspera; Amaranthaceae; achyasperoside; flavonoid C-glycoside; nitric oxide inhibitor.

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