2. Academic Validation
  3. δ-Opioid Receptor as a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development

δ-Opioid Receptor as a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development

  • Biomedicines. 2023 Jul 3;11(7):1887. doi: 10.3390/biomedicines11071887.
Natalia V Naryzhnaya 1,  Alexander V Mukhomedzyanov 1,  Maria Sirotina 1,  Leonid N Maslov 1,  Boris K Kurbatov 1,  Alexander S Gorbunov 1,  Mikhail Kilin 1,  Artur Kan 1,  Andrey V Krylatov 1,  Yuri K Podoksenov 1,  Sergey V Logvinov 2
Affiliations

Affiliations

  • 1 Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk 634021, Russia.
  • 2 Department of Histology, Embryology and Cytology, Siberian State Medical University, Tomsk 634050, Russia.
PMID: 37509526 DOI: 10.3390/biomedicines11071887
Abstract

An analysis of published data and the results of our own studies reveal that the activation of a peripheral δ2-opioid receptor (δ2-OR) increases the cardiac tolerance to reperfusion. It has been found that this δ2-OR is localized in cardiomyocytes. Endogenous opioids are not involved in the regulation of cardiac resistance to reperfusion. The infarct-limiting effect of the δ2-OR agonist deltorphin II depends on the activation of several protein kinases, including PKCδ, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are the sarcolemmal KATP channels and the MPT pore.

Keywords

KATP channels; MPT pore; heart; kinases; myocardial infarction; opioid receptors; reperfusion.

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