2. Academic Validation
  3. Neuroprotective Iridoids and Lignans from Valeriana amurensis

Neuroprotective Iridoids and Lignans from Valeriana amurensis

  • Molecules. 2023 Aug 1;28(15):5793. doi: 10.3390/molecules28155793.
Minhui Ye 1,  Xiaoju Lin 1,  Qiuhong Wang 1,  Bingyou Yang 2,  Changfu Wang 1
Affiliations

Affiliations

  • 1 Guangdong Engineering Technology Research Center for Standardized Processing of Chinese Materia Medica, School of Chinese Materia Medica, Guangdong Pharmaceutical University, No. 280 Outside Loop East Road of Higher Education Mega Center, Guangzhou 510006, China.
  • 2 Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, No. 24 HePing Road, Harbin 150040, China.
PMID: 37570763 DOI: 10.3390/molecules28155793
Abstract

Valeriana amurensis (V. amurensis) is widely distributed in Northeast China. In addition to medicines, it has also been used to prepare food, wine, tobacco, cosmetics, perfume, and functional foods. Other studies have investigated the neuroprotective effects of V. amurensis extract. As the therapeutic basis, the active constituents should be further evaluated. In this paper, six new compounds (1-6) were isolated, including five Iridoids (Xiecaoiridoidside A-E) and one bisepoxylignan (Xiecaolignanside A), as well as six known compounds (7-12). The neuroprotective effects of 1-12 were also investigated with amyloid β protein 1-42 (Aβ1-42)-induced injury to rat pheochromocytoma (PC12) cells. As a result, Iridoids 1 and 2 and Lignans 6, 8, and 9 could markedly maintain the cells' viability by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) and Lactate Dehydrogenase (LDH) release assay.

Keywords

Aβ1-42; PC12 cells; Valeriana amurensis; iridoids; lignans; neuroprotective effect.

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