1. Academic Validation
  2. Liquid Nanoparticles for Nanocatalytic Cancer Therapy

Liquid Nanoparticles for Nanocatalytic Cancer Therapy

  • Adv Mater. 2023 Sep 5;e2306469. doi: 10.1002/adma.202306469.
Ruizhi Hu 1 Xiaoying Chen 1 Zhifang Li 2 Guojun Zhao 2 Li Ding 3 Liang Chen 4 Chen Dai 1 Yu Chen 2 5 Bo Zhang 1


  • 1 Department of Ultrasound, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, P. R. China.
  • 2 Department of Emergency, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P. R. China.
  • 3 Education Institute, Tongji University School of Medicine, Tongji University Cancer Center, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, National Clinical Research Center of Interventional Medicine, Shanghai, 200072, P. R. China.
  • 4 Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.
  • 5 Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute of Shanghai University, Wenzhou, Zhejiang, 325088, P. R. China.

Nanotechnology is revolutionizing Cancer therapy, and catalyzes the emerging of ion-involved cancer-therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate from this critical issue, the glutathione (GSH)-responsive organosilica network was employed to lock the liquid drops at the nanoscale via a general bottom-up strategy to achieve the systemic delivery of "ion drugs". In this work, a sulfate radical generation donor (Na2 S2 O8 ), as a paradigm "ion drug", was entrapped into this liquid nanoparticle for efficiently delivering to the tumor region. After further surface engineering with pH-responsive tannic acid-Fe2+ framework, these liquid nanoparticles achieved tumor-microenvironmental pH/GSH-dual responsive ion release (Fe2+ /Na+ /S2 O8 2- ) after reaching the tumor sites, where the Fe2+ further triggered S2 O8 2- to generate toxic •SO4 - and •OH, effectively executing Cancer cell Ferroptosis (Fe2+ , ROS) and Pyroptosis (Na+ , ROS). Such a tumor-responsive/specific liquid nanoplatform is highly instructive for further ion-mediated nanomedicine and disease treatment. This article is protected by copyright. All rights reserved.


liquid nanoparticles; nanocatalytic medicine; sulfate radical; tumor microenvironment.