2. Academic Validation
  3. Tocotrienol monomers and dimers from the roots of Litchi chinensis with tyrosinase inhibition activity

Tocotrienol monomers and dimers from the roots of Litchi chinensis with tyrosinase inhibition activity

  • Phytochemistry. 2023 Nov 10:217:113921. doi: 10.1016/j.phytochem.2023.113921.
Awat Wisetsai 1,  Siwattra Choodej 1,  Dina Nur Shinta 1,  Sarawut Tontapha 2,  Vittaya Amornkitbamrung 2,  Paratchata Batsomboon 3,  Khanitha Pudhom 4
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
  • 2 Integrated Nanotechnology Research Center, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
  • 3 Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road Laksi, Bangkok, 10210, Thailand.
  • 4 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: [email protected].
PMID: 37952709 DOI: 10.1016/j.phytochem.2023.113921
Abstract

Four undescribed modified tocotrienols, including two monomers, litchinols A (1) and B (2), and two walsurol dimers, δ,δ-walsurol (3) and γ,δ-bi-O-walsurol (4), as well as seven known compounds (5-11) were isolated from the roots of Litchi chinensis. The structures of the undescribed compounds were elucidated based on analyses of spectroscopic data and ECD spectra. All tocotrienol derivatives (1-6) were evaluated for their Tyrosinase inhibition activity. Only monomers 1-2 and 5-6 displayed potent inhibitory activity and greater than kojic acid. Kinetic analysis revealed that the representative compound 2 was uncompetitive inhibitor with the inhibition constant value of 5.70 μM.

Keywords

Litchi; Litchi chinensis; Sapindaceae; Tocotrienols; Tyrosinase inhibition.

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