2. Academic Validation
  3. Porcine reproductive and respiratory syndrome virus triggers Golgi apparatus fragmentation-mediated autophagy to facilitate viral self-replication

Porcine reproductive and respiratory syndrome virus triggers Golgi apparatus fragmentation-mediated autophagy to facilitate viral self-replication

  • J Virol. 2024 Jan 5:e0184223. doi: 10.1128/jvi.01842-23.
Shuang-Shuang Zhao 1 2,  Qisheng Qian 1 2,  Xin-Xin Chen 2,  Qingxia Lu 2,  Guangxu Xing 2,  Songlin Qiao 2,  Rui Li 2,  Gaiping Zhang 1 2 3
Affiliations

Affiliations

  • 1 College of Veterinary Medicine, Jilin University, Changchun, Jilin, China.
  • 2 Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, China.
  • 3 Longhu Modern Immunology Laboratory, Zhengzhou, Henan, China.
PMID: 38179942 DOI: 10.1128/jvi.01842-23
Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) Infection results in a serious swine disease affecting pig farming worldwide. Despite that numerous studies have shown that PRRSV triggers Autophagy for its self-replication, how PRRSV induces Autophagy is incompletely understood. Here, we identify that PRRSV Nsp2 degrades GRASP65 to induce GA fragmentation, which dissociates RAB2 from GM130 and activates RAB2-ULK1-mediated Autophagy to enhance viral replication. This work expands our understanding of PRRSV-induced Autophagy and PRRSV replication, which is beneficial for anti-viral drug development.

Keywords

GA fragmentation; GRASP65; Nsp2; PRRSV; RAB2; ULK1; autophagy.

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