2. Academic Validation
  3. Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis

Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis

  • iScience. 2024 Mar 14;27(4):109504. doi: 10.1016/j.isci.2024.109504.
Wenxiang Feng 1,  Nan Zhu 2,  Yubin Xia 3,  Zehai Huang 2,  Jianmin Hu 1,  Zefeng Guo 1,  Yuzhuz Li 1,  Song Zhou 1,  Yongguang Liu 1,  Ding Liu 1
Affiliations

Affiliations

  • 1 Department of Organ Transplantation, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • 2 Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • 3 Department of Nephrology, First Affiliated Hospital of Shantou University Medical College, No. 57, Changping Rd, Shantou, Guangdong Province 515000, China.
PMID: 38632989 DOI: 10.1016/j.isci.2024.109504
Abstract

Kidney transplantation is essential for patients with end-stage renal disease; however, ischemia-reperfusion injury (IRI) during transplantation can lead to acute kidney damage and compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic strategy, by reducing production of Reactive Oxygen Species (ROS). Therefore, we constructed rutin-loaded polydopamine nanoparticles (PEG-PDA@rutin NPs, referred to as PPR NPs) to eliminate ROS resulting from IRI. Physicochemical characterization showed that the PPR NPs were ∼100 nm spherical particles with good ROS scavenging ability. Notably, PPR NPs could effectively enter lipopolysaccharide (LPS)-treated renal tubular cells, then polydopamine (PDA) released rutin to eliminate ROS, repair mitochondria, and suppress Ferroptosis. Furthermore, in vivo imaging revealed that PPR NPs efficiently accumulated in the kidneys after IRI and effectively protected against IRI damage. In conclusion, PPR NPs demonstrated an excellent ability to eliminate ROS, suppress Ferroptosis, and protect kidneys from IRI.

Keywords

Biological sciences; Biomedical materials; Drug delivery system; Nanoparticles.

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